Nike Running stepped away from leather and synthetic uppers and breathable mesh in 2012 when the brand introduced Flyknit. How many materials can be lighter than simple thread? The yarn upper is sewn into and held in place by a lightweight structure. The sneaker was immediately functional for Olympic sprinters and easily desirable for its comfort and aggressive coloring. From the vivid HTM designs to Supreme's all-black effort, the Flyknit continues to impress.